Spinosad works by contact and by ingestion. Spinosad
has a unique mode of action that is different from all other
known insect control products. Spinosad causes
excitation of the insect nervous system, leading to
involuntary muscle contractions, prostration with
tremors, and finally paralysis. These effects are consistent with the activation of
nicotinic acetylcholine receptors by a mechanism that is clearly novel and unique
among known insecticidal compounds.
Insecticide Resistance Action Committee (IRAC) Classification No. 5