In contrast to most commercially successful insecticides
which act on the nervous system, Flubendiamide disrupts
proper muscle function in insects and therefore represents a
novel, unique mode of action. These characteristic
symptoms are induced by Flubendiamide through the activation of ryanodinesensitive
intracellular calcium release channels (ryanodine receptors, RyR) as
shown by Ca2+ fluorescence measurements in insect neurons as well as in
recombinant cells expressing the cloned ryanodine receptor from Drosophila
melanogaster.
Insecticide Resistance Action Committee (IRAC) Classification No. 28